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KMID : 0606920090170040446
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Biomolecules & Therapeutics
2009 Volume.17 No. 4 p.446 ~ p.454
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Immunotoxicological Investigation of 1-furan-2-yl-3-pyridin-2-yl-propenone in Female BALB/c Mice
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Jeon Tae-Won
Kim Chun-Hwa
Lee Sang-Kyu
Ko Gyu-Sub
Yoo Jin-Woo
Ha Hyun-Woo
Kang Won-Ku
Jeong Hye-Gwang
Kang Mi-Jeong
Lee Eung-Seok
Jeong Tae-Cheon
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Abstract
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1-Furan-2-yl-3-pyridin-2-yl-propenone (FPP-3) has recently been synthesized and characterized to have an anti-inflammatory activity through the inhibition of the production of nitric oxide and tumor necrosis factor-■. In the present study, adverse effects of FPP-3 on immune functions were determined in female BALB/c mice. When mice were administered orally with FPP-3 at 125, 250 or 500 mg/kg for 7 consecutive days, FPP-3 suppressed the number of antibody-forming cells and reduced thymus weight at 500 mg/kg. In addition, FPP-3 administered mice exhibited reduced splenic cellularity and numbers of splenocyte subsets, such as CD3＋ cells, CD3＋CD4＋ cells, CD3＋CD8＋ cells and macrophages. IL-4 mRNA expression was significantly suppressed by FPP-3 treatment. Moreover, the number of CD4＋IL-4＋ cells was reduced following the treatment of mice with 500 mg/kg of FPP-3. These results suggested that FPP-3 at 500 mg/kg might be immunotoxic, and that FPP-3-induced immunotoxicity might be mediated, at least in part, through the inhibition of cytokine production, such as IL-4.
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KEYWORD
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1-Furan-2-yl-3-pyridin-2-yl-propenone, Immunotoxicity, Antibody-forming cells, Cytokines
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